Their approach involves injecting the virus directly into the tumour in order to overcome the blood-brain barrier. In this way he will explore and augment immunotherapy for glioblastoma in order to identify armed herpes viruses as candidates for development towards clinical trial.
Given the dismal prognosis for those diagnosed with glioblastoma, and the lack of progress over recent decades, there is a real and pressing need for research into the development of new treatments. Equally important, through this PhD studentship, we are nurturing the development of a promising young researcher who we hope will go on to develop a long and illustrious career in this under-researched and under-resourced field.
Brain tumours are one of our current research priorities , reflecting the large unmet need in this area. Our aim is to fund research to advance understanding of the causes and underlying mechanisms of brain tumours, and help us to diagnose and treat them more effectively. Find out about our other research in this area:. Shop News Contact us Search. Our research.
Neuro facts. A trial of a vaccine called DCVax-L for glioblastoma multiforme Please note - this trial is no longer recruiting patients. Cancer type: Brain and spinal cord tumours. Status: Closed. Phase: Phase 3. The aim of the trial is to see if DCVax-L helps people with glioblastoma multiforme.
Trial design This phase 3 trial will recruit about people. Hospital visits After having surgery to remove your brain tumour, you see the trial team and have some more tests. The tests include Physical examination Blood tests Urine tests MRI scan If results of these tests show that you can take part in the trial, the researchers need to collect some of your white blood cells to prepare the dendritic cells.
During treatment, you see the trial team and have blood tests and an MRI scan every 2 months. In earlier trials of DCVax-L injections, the side effects have included A reaction at the injection site such as redness, warmth and swelling, itching, or pain High temperature fever Tiredness fatigue Headache Muscle or joint pain. How to join a clinical trial Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Print page. Email this page. Questions to ask your doctor about clinical trials. Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.
Chief Investigator Prof Keyoumars Ashkan. Freephone Email. Last review date 30 November Treatment for a brain or spinal cord tumour depends on the type of tumour you have, where it is and your general health. About Cancer generously supported by Dangoor Education since Questions about cancer?
Call freephone 9 to 5 Monday to Friday or email us. Skip to main content. Read about astrocytomas in children. Find out more about the symptoms of brain tumours. Read about glial cells and the different parts of the brain. The most common type of astrocytoma in adults is glioblastoma. Find out more about grades of brain tumours. We have more information about the tests you might have to diagnose a brain tumour.
We have more information about surgery for brain tumours. Your doctor might recommend that you have radiotherapy after surgery if you: are over 40 years old have a lot of tumour left behind after surgery Find out about radiotherapy for brain tumours. Read more about surgery for brain tumours. Find out more about radiotherapy for brain tumours. You might have temozolomide: after surgery and radiotherapy if you have a grade 3 astrocytoma at the same time as radiotherapy chemoradiotherapy if you have glioblastoma We have more information about temozolomide and other types of chemotherapy for brain tumours.
Treatment for high grade astrocytoma that starts to grow again. If this happens, you might have: the chemotherapy combination PCV or lomustine more surgery more radiotherapy. Read more about follow up appointments after treatment for brain tumour. Find out about the latest UK research and how you can take part in a clinical trial. Glioblastoma Glioma. Several studies have demonstrated that acidity within tumours is greater that in normal tissue.
This effect is predominantly driven by the hypoxic low oxygen We seek permission to analyse surplus specimens resected at craniotomy. We will first separate the tumour into single cells before infecting these specimens with Zika Brain metastases Glioblastoma.
This study will test an investigational drug called AZD in combination with radiation therapy for the treatment of brain tumors. This is the first time AZD is Most patient with brain tumours develop functional disturbance weakness, balance problems, etc.
This is a single centre, proof-of-concept phase I trial.
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